Yes, I'd absolutely buy either a comic or MCU version of Karen.
I know that a lot of people don't like civilian figures but for me there are many civilian characters that are more important than a lot super powered characters. For example, Robbie Robertson, Edwin Jarvis and Rick Jones are all in my top 10 on our current poll (the rest are all X-Men). Karen doesn't rate quite that high - but I'd have both Foggy Nelson and Ben Urich in my top 25ish somewhere also.
Likewise within DC, I'd say that Alfred and Lois are more important characters than anyone outside of Batman, Robin and Superman. Maybe Jim Gordon as well. I feel pretty strongly about including civilians in figure form.