I would think Gen13 or at least Caitlin Fairchild would be a no brainer to do after Witchblade. Her suit was the most colorful and striking, but again, I dunno how that works with a rubber diaper. I liked the DV8 team, but I'm sure they're too obscure for figures if we're not getting Gen13.
I'll buy Spartan but I really want a decent 90s Grifter. Throw in Voodoo and Zealot for good measure. Put Void in a 2pk with megafig Maul or just do his smaller self in with his larger one. Ripclaw or whatever their metallic Wolverine character was called should round out the rest (I always get him confused with the Cyberforce equivalent). Don't know that I need their dwarven handler or John Lynch though if we're not gonna' have time to expand on the team much. Don't feel like the villains were really ever all that cool personally, so even if they made them I don't know that I'd buy them.
Would be fun to see McFarlane's version of Eric Draven's The Crow and SCUD the Disposable Assassin.